Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking
نویسندگان
چکیده
منابع مشابه
Cholesterol‐enriched membrane rafts and insulin secretion
The failure of pancreatic β-cells to supply insulin in quantities sufficient to maintain euglycemia is a hallmark of type 2 diabetes. Perturbation of β-cell cholesterol homeostasis, culminating in elevated intracellular cholesterol levels, impairs insulin secretion and has therefore been proposed as a mechanism contributing to β-cell dysfunction. The manner in which this occurs, however, is unc...
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ژورنال
عنوان ژورنال: Traffic
سال: 2012
ISSN: 1398-9219
DOI: 10.1111/j.1600-0854.2012.01407.x